Yes, you can.
Nova Drive is the ultimate G-System accessory. A connected Nova Drive will automatically be discovered through plug-and-play technology. Once they are hooked up, you get full access to all Nova Drive parameters, preset select and routing from the G-System menu as if Nova Drive was an internal G-System effect. This even includes modifiers, making it possible to control the amount of distortion or overdrive in real-time using your G-System's expression pedal.